Impact of NSAID type, initiation timing, duration and dose on clinical outcomes of immunotherapy in NSCLC: a multicenter two-cohort study.

J Immunother Cancer · 2026 · PMC13052584 · PMID 41922087

Europe PMC DOI

hedged sentences

0.1094

closest p · 2.2× alpha

0.1094

boldest claim

The sentences

showed a trendp=0.1094not close (p > 0.1)

Non-selective NSAIDs showed a trend (HR 0.85, 95% CI 0.69 to 1.04, p=0.1094) without reaching statistical significance, and initiation timing, duration, or dose did not significantly affect PFS in this subgroup.

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did not reach statistical significanceno p-value reported

Although other NSAIDs did not reach statistical significance, after-ICI initiation of non-selective NSAIDs yielded an OS advantage.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.