Alzheimer's disease risk protein SorLA regulates ER homeostasis and lipid metabolism in human microglia, with conserved effects in neurons.

Acta Neuropathol · 2026 · PMC13053485 · PMID 41942750

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0600

boldest claim

The sentences

highly significantp < 1 × 10 −15actually significant

The Kruskal–Wallis test revealed a highly significant difference among groups ( H = 10,029.68, p < 1 × 10 −15 ).

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showed a trendp = 0.06so close (0.05 < p ≤ 0.1)

sXBP1 and CHOP showed a trend toward reduction with p values approaching statistical significance (p = 0.06).

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did not reach statistical significanceno p-value reported

6 l,l′) and a significant reduction in BiP mRNA levels, while other ER stress markers ( sXBP1 and CHOP ) showed trends toward reduction that did not reach statistical significance (Supplementary extended data Fig. 6 b).

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