Elevated ANGPTL8 (Angiopoietin-Like Protein 8) Levels as a Novel Predictor of Atherosclerosis in Type 2 Diabetes: Beyond Lipid Metabolism.

After full adjustment, participants in the highest ANGPTL8 quartile had a 3.37‐fold increased risk of elevated C‐IMT compared with those in the lowest quartile (OR, 3.37 [95% CI, 1.45–7.82]; P =0.005), with a significant trend across quartiles ( P =0.030) and an 82% higher risk per SD increase in ANGPTL8 (OR, 1.82 [95% CI, 1.36–2.43]).

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Enhanced model 1 (incorporating LDL cholesterol, triglycerides, TC, and HDL cholesterol) and enhanced model 2 (adding age and sex to model 1) showed modest improvements in discrimination (AUC, 0.56 [95% CI, 0.48–0.64]; and AUC, 0.57 [95% CI, 0.49–0.65], respectively), but these improvements did not reach statistical significance compared with the basic model ( P =0.27 and P =0.23, respectively; Table S3 ).

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