Outcomes Associated With Early Initiation and Rapid Uptitration of Heart Failure Treatment in Patients With Ejection Fraction <50%: Real-Life Data From the Swedish Heart Failure Registry 2003 to 2022.

J Am Heart Assoc · 2026 · PMC13055828 · PMID 41804891

Europe PMC DOI

hedged sentences

0.1400

closest p · 2.8× alpha

0.1400

boldest claim

The sentences

did not reach statistical significanceP =0.14not close (p > 0.1)

After IPTW adjustment, this difference did not reach statistical significance (aHR, 0.68 [95% CI, 0.41–1.13], P =0.14).

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a strong trendno p-value reported

This risk reduction began to show a strong trend as early as 3 months, although it did not reach statistical significance after adjusting for age, sex, and comorbidities.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Outcomes Associated With Early Initiation and Rapid Uptitration of Heart Failure Treatment in Patients With Ejection Fraction &lt;50%: Real-Life Data From the Swedish Heart Failure Registry 2003 to 2022.

The sentences

Outcomes Associated With Early Initiation and Rapid Uptitration of Heart Failure Treatment in Patients With Ejection Fraction <50%: Real-Life Data From the Swedish Heart Failure Registry 2003 to 2022.