Fungal microbiota signatures anticipate neoadjuvant immunochemotherapy outcomes in esophageal cancer.

At the genus level ( figure 2H ), g_Meyerozyma , g_Trichosporon , and g_Cryptococcus emerged as highly significant indicators for the healthy state, while g_Atradidymella demonstrated strong association with the pretreatment group.

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NMDS analysis using Jaccard distance further supported these findings, showing a clear trend of separation between the NR and R groups ( figure 4B,C ).

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Overall, NICT treatment showed a trend toward improvement in fungal community diversity and richness metrics, but full recovery to healthy levels was not achieved ( figure 1A ).

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