Day + 30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML.

BMC Med · 2026 · PMC13063694 · PMID 41772567

Europe PMC DOI

hedged sentences

0.2330

closest p · 4.7× alpha

0.2330

boldest claim

The sentences

showed a trendp = 0.233not close (p > 0.1)

Regarding other transplant outcomes, FLT3-ITD –positive patients showed a trend toward increased CIR (2-year CIR: 22.8% [95% CI, 21.8–23.9] vs. 15.2% [95% CI, 14.8–15.5], p = 0.233), as well as inferior OS (2-year OS: 70.9% [95% CI, 57.0–88.0] vs. 76.0% [95% CI, 67.3–85.8], p = 0.399); however, none of these differences reached statistical significance (Fig. 3 B and C).

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did not reach statistical significancep = 0.051so close (0.05 < p ≤ 0.1)

a favorable trendno p-value reported

MFC-MRD–free survival showed a favorable trend in the maintenance group, although this did not reach statistical significance (2-year MFC-MRD–free survival: 85.5% [95% CI, 74.4–98.3] vs. 68.7% [95% CI, 57.3–82.4], p = 0.051).

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