Spatial distribution analysis of tertiary lymphoid structures in esophageal squamous cell carcinoma predicts patient survival and response to neoadjuvant chemo-immunotherapy.

J Transl Med · 2026 · PMC13064296 · PMID 41776661

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did not reach statistical significanceno p-value reported

Additionally, in patients with a high density of total TLSs, the increase in Foxp3 + Tregs in both the proximal and distal did not reach statistical significance (Fig. 4 D).

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showed a trendno p-value reported

However, patients with a high number and density of distal TLSs showed a trend toward better survival than those with a low number and density of distal TLS; however, this difference was not statistically significant.

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