HPV status determines prognostic gene expression methylation and immune infiltration in head and neck squamous cell carcinoma.

Discov Oncol · 2026 · PMC13065962 · PMID 41776121

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0100

boldest claim

The sentences

a negative trendp < 0.01actually significant

For MFAP2, a positive correlation with Treg cells ( p < 0.01) and a negative trend with CD4+T cells ( p < 0.01) were observed, but its negative correlation with CD8+T cells lacked statistical.

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did not reach statistical significanceno p-value reported

Consistent with our primary analysis, seven genes (LAMC2, MFAP2, CTHRC1, CXCL13, FST, SPP1, and PLAU) were significantly overexpressed in head and neck cancer tissues compared to normal controls (all p < 0.01), while CDKN2A did not reach statistical significance in this analysis (Supplementary Figure S1).

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