A high density of T-cell lymphocytes and Tregs subset correlate to a worse survival in major salivary gland carcinomas.

Moreover, Kaplan–Meier analysis suggested a trend in which higher intratumoral M2 macrophage density is associated with poorer prognosis, although this observation did not reach statistical significance in the log-rank test.

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Notably, the increasing in M2 macrophages (co-expressing CD68 and CD163) showed a trend with worse PFS, but without statistical significance (Fig. 1 ).

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