A redox sensor in protein kinase A regulatory subunit Iα regulates vasodilation and protects against hypertension.

In addition, transgenics showed a trend toward a reduced chronotropic response following bolus administration of the β-adrenergic agonist isoproterenol compared with WT controls ( Fig. 4 C).

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Interestingly, mesenteric arteries from PKA KI mice generated greater force in response to depolarization with potassium chloride (60 mM) than WT controls, whereas constriction to U-46619 (100 nM) did not reach statistical significance ( Fig. 1 H).

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