Identification of Hidden Cachexia Subgroup in PD-L1-High NSCLC: Comparative Analysis of the AWGC vs. Fearon Criteria.

J Cachexia Sarcopenia Muscle · 2026 · PMC13070542 · PMID 41967103

Europe PMC DOI

hedged sentences

0.0720

closest p · 1.4× alpha

0.0720

boldest claim

The sentences

a nonsignificant trendp = 0.072so close (0.05 < p ≤ 0.1)

48.5 months, adjusted HR 1.539, p = 0.003), while progression‐free survival (PFS) under PD‐1/PD‐L1 inhibitor therapy or chemoimmunotherapy showed a nonsignificant trend (7.1 vs. 13.0 months, adjusted HR 1.253, p = 0.072).

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did not reach statistical significancep = 0.072so close (0.05 < p ≤ 0.1)

showed a trendp = 0.072so close (0.05 < p ≤ 0.1)

In the multivariate Cox regression analysis adjusted for age, ECOG PS, histology, disease stage, PD‐L1 status, presence of metastases and treatment regimen, the association with OS remained significant (adjusted HR: 1.539, 95% confidence interval [CI]: [1.156–2.048], p = 0.003), whereas PFS showed a trend toward shorter survival that did not reach statistical significance (adjusted HR: 1.253, 95% CI: [0.980–1.602], p = 0.072) (Table 2 ).

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