Although there is a clear trend in the summary results of the meta-analysis, it is based on only a few observation studies and hence the findings should be viewed as proof of principle.
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Treatment-modifying effects of frailty on stroke reperfusion therapy outcomes: a systematic review and meta-analysis.
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Post-reperfusion morbidity There was a trend towards premorbid frailty being associated with an increased risk of mRS 3–5 versus mRS 0–2 at 90-days post-reperfusion therapy, though it did not reach statistical significance [5 studies, RR 2.20 (0.94–5.16)].