Association Between Irinotecan-Containing Regimens and Functional and Nutritional Impairment in Advanced Colorectal Cancer: An Exploratory PG-SGA Analysis.

Although most gastrointestinal symptoms did not reach statistical significance, early satiety ( p = 0.041) and functional deterioration ( p = 0.039) were significantly associated with irinotecan administration, while nausea ( p = 0.089) and vomiting ( p = 0.087) showed trends toward significance.

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Global Integration of Nutritional Scores The combination of symptoms approaching significance (nausea and vomiting) together with the significant associations observed for early satiety and functional deterioration resulted in higher total PG-SGA scores in patients treated with irinotecan, particularly in combination with FOLFOX, compared with FOLFOX alone and XELOX.

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