Plasma biomarkers of Alzheimer's disease and their association with disproportionately enlarged subarachnoid space hydrocephalus.

Again, the group with high p-tau217 and normal PET group did not reach statistical significance but showed a trend towards significant association with DESH, suggesting that these differences may be dictated by plasma biomarker factors more so than amyloid PET elevation, but the variance was also greater in the p-tau217 analyses.

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Although the group with low Aβ42 and normal amyloid PET group did not reach statistical significance, the effect was in the expected direction, suggesting the signal may be driven by AD plasma-biomarker change rather than amyloid PET elevation.

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