<i>miR-122</i> Deficiency in Mice Enhances Regeneration in Healthy Liver but Drives Pathological Repair and Functional Decline in Fibrotic Liver.

Furthermore, miR-122-silenced mice exhibited a trend toward increased mortality, although this did not reach statistical significance ( p = 0.308; Supplementary Figure S3F ).

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This approach resulted in significantly impaired fibrosis resolution following partial hepatectomy and a clear trend toward increased mortality, confirming that miR-122 deficiency directly contributes to hepatic dysfunction and reduced survival independent of initial fibrosis severity.

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