Colchicine for the Prevention of Major Adverse Cardiovascular Events After Acute Coronary Syndromes: A Systematic Review and Meta-Analysis of Large, Long-Term, Placebo-Controlled Randomized Trials.

J Clin Med · 2026 · PMC13073614 · PMID 41976993

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did not reach statistical significanceno p-value reported

In the present meta-analysis, although the diabetes subgroup analysis did not reach statistical significance, the direction and magnitude of effect suggest a possible signal of benefit.

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showed a trendno p-value reported

Moreover, subgroup analyses showed a trend toward benefit in the pre-pandemic cohort, which faded during and after the pandemic.

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