<i>Roseburia</i>-Associated Gut-Brain Axis Alterations in Relapsing-Remitting Multiple Sclerosis: Evidence from a Household-Matched Case-Control Study.

Nutrients · 2026 · PMC13074294 · PMID 41978167

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0.0600

closest p · 1.2× alpha

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boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

This reduction was statistically significant for the Fisher index (adj p = 0.02, Figure 1 A), while it did not reach statistical significance for the Chao1 index (adj p = 0.06, Figure 1 B).

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a possible trendno p-value reported

A nominal between-group difference was detected between healthy controls and the high MSSS group ( p = 0.024; adj p = 0.144, Figure 2 C), indicating a possible trend toward altered microbial composition with greater disease severity.

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showed a trendno p-value reported

In contrast, individuals with severe MS showed a trend toward reduced richness, suggesting a possible link between microbial loss and advanced neurologic impairment.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

&lt;i&gt;Roseburia&lt;/i&gt;-Associated Gut-Brain Axis Alterations in Relapsing-Remitting Multiple Sclerosis: Evidence from a Household-Matched Case-Control Study.

The sentences

<i>Roseburia</i>-Associated Gut-Brain Axis Alterations in Relapsing-Remitting Multiple Sclerosis: Evidence from a Household-Matched Case-Control Study.