Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits.

Heart Rhythm · 2026 · PMC13075518 · PMID 41513056

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a nonsignificant trendno p-value reported

35 In our study, atrial fibrosis showed a nonsignificant trend toward an increase in aged rabbits and human AF samples ( Supplemental Figures 1 and 2 ), consistent with high interindividual variability.

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did not reach statistical significanceno p-value reported

However, slowing of CV reduction ( P = .24) and APD prolongation ( P = .39) did not reach statistical significance owing to increased intragroup variation in aged rabbits (standard deviation [SD] of CV 0.08 m/s in young vs 0.12 m/s in old; SD of APD 6 ms in young vs 19 ms in aged).

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showed a trendno p-value reported

In human AF samples, SA-β-Gal+ cell numbers showed a trend toward an increase but varied significantly (1%–9%), with no statistical difference between AF and SR groups ( Figure 6C ).

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