Gastric cancer prevention by <i>H. pylori</i> eradication in China: a meta-analysis of 8 high-quality RCTs in targeted screening populations.

After excluding the 2012 study ( Figure 4F ), the I2 value in the ≤5-year follow-up group decreased to 0, with RR = 0.50 and P = 0.20, and the result still did not reach statistical significance.

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For follow-up duration, the subgroup with ≥10 years of follow-up showed a 47% reduction in gastric cancer risk (RR = 0.53, P<0.0001), while short-term intervention (≤5 years) showed a trend toward reduced risk without reaching statistical significance.

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