DNA methylation driven genes shape prognosis and tumor immune landscape in rectal cancer.

Discov Oncol · 2026 · PMC13079259 · PMID 41790364

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0620

boldest claim

The sentences

highly significantp < 2.2e − 16actually significant

ST6GALNAC1 expression showed highly significant tumor–normal differences in both external datasets ( GSE71187 and GSE87211 ; Wilcoxon p < 2.2e − 16 in each; Fig. 13 A), providing the most consistent external expression evidence among the three model genes.

also in 132,142 other papers

borderline significancep = 0.062so close (0.05 < p ≤ 0.1)

Similarly, relapse-free survival displayed a separation trend with borderline significance (log-rank p = 0.062; Fig. 10 D).

also in 7,017 other papers

did not reach statistical significancep = 0.2not close (p > 0.1)

showed a trendno p-value reported

Kaplan–Meier analysis for overall survival showed a trend toward poorer survival in the high-risk group but did not reach statistical significance (log-rank p = 0.2; Fig. 10 C).

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.