The effect of a topical curcumin formulation (VAS-101) on knee pain in adults with knee osteoarthritis: a randomised, double-blind, placebo-controlled study.

Front Pain Res (Lausanne) · 2026 · PMC13079332 · PMID 41994034

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0860

boldest claim

The sentences

failed to reach statistical significancep > 0.05actually significant

However, a hierarchical order of secondary efficacy endpoints is detailed in Supplementary Table S1 , in which statistical significance was no longer reported after the first endpoint failed to reach statistical significance ( p > 0.05). 3.

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did not reach statistical significancep = 0.086so close (0.05 < p ≤ 0.1)

Moreover, 32.1% of participants in the VAS-101 group achieved an MCID, compared to 13.3% in the placebo group; however, this difference did not reach statistical significance ( p = 0.086).

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