Mature-onset obesity in p62-deficient male mice maintains skeletal muscle mass despite metabolic dysfunction.

3.5 Tissue weights and muscle morphology At study termination, spleen weight showed a strong trend toward being increased in p62 − / − mice compared to controls (+106.8%, p = 0.056; Figure 3a ).

also in 5,725 other papers

There was a trend toward elevated tumor necrosis factor‐α (TNF‐α) expression in the gastrocnemius of p62 − / − mice (+179.9%, p = 0.057; Figure 4b ), although this did not reach statistical significance. 4 DISCUSSION The present investigation provides insights into the relationship between p62 deficiency, metabolic dysfunction, and skeletal muscle health at an intermediate timepoint (34 weeks).

also in 111,027 other papers