Barely Significant
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Precision nutrition for NAFLD: a mechanistic rationale for targeting the cytokine landscape.

Front Cell Dev Biol · 2026 · PMC13079653 · PMID 41993593

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Furthermore, in an experimental model of NASH induced in ovariectomized mice, supplementation with 1,25(OH) 2 D 3 demonstrated modest reductions in hepatic mRNA expression of the pro-inflammatory cytokines TNF-α and IL-6; however, these effects did not reach statistical significance.

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a strong trendno p-value reported
This anti-inflammatory effect was evidenced by a marked downregulation of key pro-inflammatory cytokine and chemokine gene expression, including MCP-1 and IL-1α, with a strong trend toward reduced TNF-α expression ( Harari et al., 2020 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.