Direct and indirect genetic effects of birthweight predisposition on child DNA methylation at birth.

Epigenetics · 2026 · PMC13081746 · PMID 41979563

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nominally significantno p-value reported

When aggregating DNAm sites into an MPS-BW, a one SD higher PGS child was associated with 0.08SD (95% CI[0.04, 0.11], p < .001) higher MPS-BW ( Figure 3 ). Maternal PGS showed nominally significant associations with 80 probes, which did not pass correction for multiple testing (Table S3, S3a, S3b).

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showed a trendno p-value reported

When analyzing birthweight as the outcome (Table S7), only the PGS maternal-effect showed a trend for sex-interaction.

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