High-fat diet-driven gut microbial sphingolipid metabolic reprogramming is associated with stress susceptibility in CUMS rats.

Front Microbiol · 2026 · PMC13082169 · PMID 41994276

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showed a trendno p-value reported

Our findings indicated that HFD intervention showed a trend toward aggravating depressive behaviors and resulted in significantly more severe neuronal injury in the hippocampus relative to the ND-CUMS group.

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did not reach statistical significanceno p-value reported

While the behavioral differences between HFD-CUMS and ND-CUMS groups did not reach statistical significance in the OFT, the observed trends in total distance and immobility time suggest a potential latent burden imposed by HFD, which may predispose rats to more severe psychomotor retardation under chronic stress.

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