UUO isotype control kidneys showed a trend toward increased ICAM-1 expression in PTC compared with platelet-depleted animals, consistent with Icam1 mRNA, although the difference did not reach statistical significance (median 2 vs. 1; p = 0.0506, Mann–Whitney test, Fig. 2 F).
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Activated platelets promote endothelial dysfunction and monocyte recruitment in early renal microvascular injury.
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