Analysis of gut microbiota in Restless Legs Syndrome: searching for a metagenomic signature.

Alpha diversity tended to be higher in the RLS patients without sensory symptoms, although it did not reach statistical significance; one could speculate that this increase might play a protective role against developing a more severe phenotype.

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Eggerthellaceae was significantly reduced in RLS versus INS ( q -value = .015; Figure 2 and Data Set S1 ), while Bacteroidaceae and Marinifilaceae showed a trend toward decrease.

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