Consistent with lower TNFa expression, we found a strong trend for reduced IL-6 mRNA levels upon C3 lowering, confirming a less inflammatory microenvironment in APP;C3 iKO mice.
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C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline.
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No notable changes were observed in C1qa mRNA, although C1q b and C1qc mRNAs were modestly reduced but did not reach statistical significance in TAM-treated APP;C3 iKO mice ( Fig.
TAM-treated APP;C3i KO mice exhibited a slight trend towards reduced total distance traveled compared to CO-injected mice ( Fig. 2A ), along with a tendency for increased time spent in the central arena ( Fig. 2B ).