Sequential invitations to FOBT screening and colorectal cancer incidence.

Sci Rep · 2026 · PMC13090354 · PMID 41998115

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an increasing trendno p-value reported

1 a, there was an increasing trend along the sequences from (0, 0, 0, 0, g) to (g, g, f, f, f), though non-significantly with p-value equal to 0.085.

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a significant trendno p-value reported

Furthermore, a significant trend was observed for the effectiveness of the screening program on reducing stages III-IV along the sequences from (0, 0, 0, 0, g) to (g, g, g, f, f) post screening.

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did not reach statistical significanceno p-value reported

We demonstrated a decreased trend in the incidence of early-stage CRC with increasing numbers of invitations and with FIT sequences, although the individual FIT sequences did not reach statistical significance in our study.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.