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The Aberrant Activation of NLRP3 in Microsatellites Stability Colon Cancer Promotes M2 Macrophage Polarization Based on the TCGA Database and Tissue Microarray Analysis.

Cancer Rep (Hoboken) · 2026 · PMC13093411 · PMID 41847892

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showed a trendno p-value reported
However, although high infiltration of CD8 + T lymphocytes showed a trend toward better prognosis, the difference compared to the low infiltration group did not reach statistical significance.

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Our findings revealed that patients in the high NLRP3 expression group exhibited a notable increase in M2 macrophages and a reduction in T lymphocyte infiltration within the tumor microenvironment, although these differences did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.