Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal-Like Epithelial State.

The resulting nominally significant genes ( p ‐value ≤ 0.05 and absolute log2FC ≥ 3) were clustered based on their expression patterns using degPatterns from the DEGreport package (v 1.32.0).

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More detailed analysis of T cell subpopulations showed that CD4 + T helper cells were significantly increased, while CD8 + T cells and FoxP3 + regulatory T cells showed increasing trends that did not reach statistical significance.

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