Serum microbiome-related metabolites-including short-chain fatty acids and indole derivatives-predict outcome and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a two-timepoint LC-MS study.

Front Neurol · 2026 · PMC13095518 · PMID 42021774

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.1080

boldest claim

The sentences

near-significantp = 0.051so close (0.05 < p ≤ 0.1)

Tryptophan on day 1 demonstrated a near-significant relationship (OR = 0.53, 95% CI 0.28–1.00; Wald χ 2 = 3.8; p = 0.051; R 2 = 0.64).

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did not reach statistical significancep = 0.108not close (p > 0.1)

Propionic acid on day 1 did not reach statistical significance (OR = 0.66, p = 0.108), in contrast to its day 9 level, which was significantly associated with DCI (OR = 0.51, 95% CI 0.32–0.81; Wald χ 2 = 8.2; p = 0.004; R 2 = 0.52).

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