Preclinical identification and clinical validation of dynamic biomarkers for trifluridine/tipiracil with or without bevacizumab in metastatic colorectal cancer.

ESMO Gastrointest Oncol · 2026 · PMC13098461 · PMID 42022131

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did not reach statistical significanceno p-value reported

Although formal interaction testing did not reach statistical significance, these data suggest a regimen-dependent effect of EREG dynamics that warrants further investigation.

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showed a trendno p-value reported

At baseline, IL-8, VEGF, and IFI16 levels were not significantly correlated with disease control, whereas lower AREG and EREG levels showed a trend toward improved response in the overall cohort.

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