A similar effect direction was noted when isolating for thrombotic events at 30 days, although this did not reach statistical significance (4.9% vs 4.5%; OR, 0.57; 95% CI, 0.28-1.16; I 2 = 34%).
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Continuous vs interrupted direct oral anticoagulants for minimal bleeding-risk surgical procedures-a systematic review and meta-analysis.
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Total complications were assessed by 9 studies ( n = 2021 patients), with a pooled OR that failed to reach statistical significance, with no observed heterogeneity (6.1% vs 5.9%; OR, 1.05; 95% CI, 0.71-1.54; I 2 = 0%) ( Figure 6 ). 3.4.
Twenty studies examined bleeding events, with a significant reduction in major bleeds favoring continuous DOACs (OR, 0.57; 95% CI, 0.37-0.87; I 2 = 0%), which failed to reach significance in the randomized data.