A novel immune-related gene signature stratifies prognosis and characterizes the tumor immune microenvironment in head and neck squamous cell carcinoma.

Although the differences did not reach statistical significance, a clear trend was observed in GSE78220 and GSE91061 , with low-risk patients more likely to benefit from ICB therapy.

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Although the distribution of risk scores across different response categories did not reach statistical significance in any of the cohorts ( Figures 9c,f,i ), patients who achieved objective responses (CR/PR) exhibited a tendency toward lower risk scores compared with those with non-response (SD/PD).

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