Residential green space, air pollution, and related metabolites in association with depression among cancer survivors.

Notably, compared with cancer survivors in the lowest tertile of blue space exposure at 300 m buffer, those in the highest tertile had a significantly lower risk of depression in Model 3 (hazard ratio [HR] = 0.867, 95% confidence interval [CI] = 0.763–0.986), with a significant trend ( P trend = 0.031).

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When metabolic signatures were categorized into three groups (Low, Intermediate, high exposure), we found that metabolic signatures associated with green space and natural environment were generally inversely related to depression risk, whereas these linked to the APS were positively related; however, these associations did not reach statistical significance in the fully adjusted model.

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