Diverse genomic and transcriptomic heterogeneity in EGFR-mutant lung adenocarcinoma between exon 19 del and exon 21 L858R.

Cell Commun Signal · 2026 · PMC13101146 · PMID 41826981

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showed a trendno p-value reported

Although no statistically significant differences were observed between the 19 Del and 21 L858R cohorts in both SNV and CNV ITHi, the 21 L858R cohort numerically showed a trend toward higher CNV ITHi levels (Figure S2).

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did not reach statistical significanceno p-value reported

Although the difference did not reach statistical significance, the 21 L858R cohort demonstrated a broader spectrum of driver gene mutation trajectories.

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