Fasting and Caloric Restriction Activate an ADIOL-NHR-91-Kynurenine Pathway Signaling Axis to Promote Healthspan.

ADIOL‐treated animals showed a trend toward modestly increased resistance to osmotic stress (NaCl) (Figure S3B ).

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In nhr‐91 mutants, fasting similarly elevated Kyn and Ant levels, although the reduction in Trp did not reach statistical significance (Figure 7A,B,D ).

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