Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle.

At the myofiber level, IHC analysis revealed an average reduction in fiber type‐specific cross‐sectional area (fCSA) after atrophy, which approached significance when pooling fast and slow fibers (Figure 1H–K ).

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Mean MVC at 60° and 30° knee flexion also demonstrated the same trend but did not reach statistical significance ( p = N.S ., Figure S2K,L ).

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