Immunomodulatory and Anti-Inflammatory Effects of Ketotifen Versus Vitamin E in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Pilot Study.

Drug Des Devel Ther · 2026 · PMC13110014 · PMID 42039690

Europe PMC DOI

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0.0513

closest p · 1.0× alpha

0.0513

boldest claim

The sentences

borderline non-significantp = 0.0513so close (0.05 < p ≤ 0.1)

Waist circumference was borderline non-significant after adjustment (adjusted p = 0.0513), while outcomes that were non-significant in the primary analyses — including body weight, BMI, MACK-3 score, triglycerides, LDL-C, total cholesterol, HbA1c, waist–hip ratio, and HDL-C — remained non-significant ( Table 10 ).

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did not reach statistical significanceno p-value reported

Specifically, the adjusted mean difference (AMD) in BMI (ketotifen − vitamin E) was −0.761 kg/m 2 (95% CI: −1.809 to 0.287; p = 0.155), indicating a numerically greater reduction in the ketotifen group; however, this difference did not reach statistical significance.

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borderline significanceno p-value reported

Waist circumference showed borderline significance after adjustment, while outcomes that were non-significant in the primary analysis remained non-significant.

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