Deciphering the peripheral immune landscape of Alzheimer's disease through integrated multi-omics research and cohort validation.

PLEKHA1 showed a nominally significant MCI versus CN difference (T = 2.11, P = 0.036, FDR P = 0.225), and TBK1 did not reach significance ( Supplementary Table S28 ).

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Partial correlation adjusting for age, sex, and APOE ε4 revealed a positive association between PLEKHA1 expression and CSF total tau (partial r = 0.102, P = 0.036) ( Supplementary Figure S18 ), while PTK2B showed a trend-level inverse correlation with CSF Aβ42 (partial r = −0.078, P = 0.11) ( Supplementary Figure S19 ).

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For the genes PLEKHA1 (FDR = 2.10×10 −4 ), PTK2B (FDR = 2.50×10 −4 ), and TBK1 (FDR = 2.30×10 −4 ), their association signals with AD remained highly significant after the COJO analysis ( Supplementary Figures S14 – S16 ).

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