Cross-Linked Versus Linear Hyaluronic Acid for Cartilage Repair in Rat Post-Traumatic Osteoarthritis.

While the OA/HA group also showed a trend toward cartilage preservation (Week 12: 6.5 ± 2.08), this did not reach statistical significance compared to the OA group at any time point. 3.3 Immunohistochemical Analysis of Cartilage Metabolism and Inflammatory Markers 3.3.1 Type II Collagen (COL II) Expression COL II expression followed a treatment‐dependent pattern throughout the study period (Figure 2 ).

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