Multi-omics reveals molecular signatures of moderate intensity exercise and identifies candidate exercise mimetics in mice.

Low-dose sulpiride showed a trend toward increased grip strength (P = 0.058) and running endurance (P = 0.063), while a significant difference was observed between low- and high-dose groups in running distance (P < 0.05), indicating possible inverse effects at higher doses.

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5 K; drug effect: P = 0.491, power = 0.113; exercise effect: P = 0.012, power = 0.816), whereas the type I fiber cross-sectional area showed a downward trend that did not reach statistical significance ( Fig. 5 J; drug effect: P = 0.073, power = 0.505; exercise effect: P = 0.389, power = 0.150).

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