Electrophysiological Characterization of the Venom and Toxins from the Scorpion <i>Tityus championi</i> Targeting Voltage-Gated Sodium Channels and Molecular Modeling of Tch3, a Toxin with Therapeutic Potential for Pain Relief.

championi venom on mammalian Na V isoforms, and we showed a clear trend with increased currents carried by Na V 1.2 ( Figure 1 a) and a significant increase in Na V 1.6 ( Figure 1 d), in contrast to the decreased currents through Na V 1.7 ( Figure 1 e).

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On the other hand, under 0.075 μg/μL venom treatment, the activation curve showed a trend suggesting a smaller voltage sensitivity in the steady-state activation with a positive shift in V 1/2 compared to the control condition ( Figure 3 b left panel, and Supplementary Table S1 ).

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