Baseline Composite Score for 12-Month Clinical Remission in Biologic-Treated Severe Asthma: Development of the Base4Score.

In contrast, the unweighted 1–4 score—assigning one point per abnormal domain without empirical weighting— showed a weaker association and did not reach statistical significance ( Table 3 ).

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Remission occurred in 8/20 (40.0%) of patients with low baseline scores (<5), 3/17 (17.6%) of those with intermediate scores (5–<9), and only 5/40 (12.5%) of patients with high scores (≥9), with a significant trend across categories (linear p -trend = 0.022).

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