Investigation of Contrast-Induced Neurotoxicity and the Effects of Sildenafil and <i>N</i>-Acetylcysteine on HIF-1α Levels in Wistar Rats.

Although ELISA analysis indicated no significant differences in HIF-1α levels among groups ( p = 0.119), immunohistochemical analysis revealed highly significant differences in HIF-1α immunoreactivity ( p < 0.001), with highest expression in Group B (CMA + Saline) and lowest in Group D (CMA + SIL), while Group C (CMA + NAC) showed intermediate levels.

also in 132,142 other papers

The primary biochemical endpoint (tissue HIF-1α by ELISA) did not reach statistical significance across groups.

also in 111,027 other papers

The sildenafil-treated group showed a trend toward lower HIF-1α immunoreactivity compared to the contrast media group, with a medium effect size (Cohen’s d = 0.71), though this difference did not reach statistical significance after correction for multiple comparisons (Dunn’s test, p = 0.050).

also in 53,322 other papers