Barely Significant
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<i>CDKN2A</i>/<i>p16</i> Exon 2 Hypermethylation in Lung Squamous Cell Carcinoma Associated with Interstitial and Emphysematous Lung Diseases: A Comparative Analysis of Tumor, Adjacent and Distant Lung Tissues.

Curr Oncol · 2026 · PMC13114730 · PMID 42041706

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did not reach statistical significancep = 0.052so close (0.05 < p ≤ 0.1)
showed a trendno p-value reported
In contrast, patients with PE exhibited significantly higher methylation levels in T compared with D tissues ( p = 0.035), while A tissues showed a trend toward higher methylation compared with D tissues, although this difference did not reach statistical significance ( p = 0.052).

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