Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Patients Undergoing Aortic Valve Replacement for Severe Aortic Stenosis: A Retrospective Cohort Study.

J Clin Med · 2026 · PMC13116288 · PMID 42074707

Europe PMC DOI

hedged sentences

0.0380

closest p · 0.8× alpha

0.0750

boldest claim

The sentences

nominally significantp = 0.038actually significant

Among diabetic patients, a nominally significant difference in unadjusted event rates was observed (12% vs. 35%, p = 0.038), though this exploratory subgroup analysis requires cautious interpretation given the small sample and absence of adjustment for confounders. 4.1.

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did not reach statistical significancep = 0.075so close (0.05 < p ≤ 0.1)

After multivariable adjustment for confounders including age, diabetes, and hypertension, the association did not reach statistical significance (adjusted OR 0.33, 95% CI 0.10–1.12, p = 0.075).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.