Genetic Variation in <i>CYP2B6</i>, <i>UGT1A4</i> and Sulfotransferases Is Associated with Disease-Free Survival in South African Breast Cancer Patients Treated with Tamoxifen.

J Pers Med · 2026 · PMC13117320 · PMID 42042555

Europe PMC DOI

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0.0440

closest p · 0.9× alpha

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boldest claim

The sentences

nominally significantp = 0.044actually significant

Heterozygotes for SULT1E1 rs3775779 demonstrated reduced DFS in univariate analysis, which remained nominally significant in the multivariate model (HR = 2.52; 95% CI = 1.02–6.18; p = 0.044).

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showed a trendno p-value reported

In the present study, the UGT1A4 rs11888492 intronic variant showed a trend toward improved DFS in the multivariate analysis.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Genetic Variation in &lt;i&gt;CYP2B6&lt;/i&gt;, &lt;i&gt;UGT1A4&lt;/i&gt; and Sulfotransferases Is Associated with Disease-Free Survival in South African Breast Cancer Patients Treated with Tamoxifen.

The sentences

Genetic Variation in <i>CYP2B6</i>, <i>UGT1A4</i> and Sulfotransferases Is Associated with Disease-Free Survival in South African Breast Cancer Patients Treated with Tamoxifen.