Impact of germline genetic variation on breast cancer prognosis: a systematic review and meta-analysis.

BMC Cancer · 2026 · PMC13122941 · PMID 41781907

Europe PMC DOI

hedged sentence

0.0610

closest p · 1.2× alpha

0.0610

boldest claim

The sentences

showed a trendp = 0.061so close (0.05 < p ≤ 0.1)

did not reach statistical significanceno p-value reported

The analysis for Progression-Free Survival (PFS) showed a trend towards increased risk (HR = 2.68; 95% CI: 0.98–7.52; p = 0.061; I 2 = 80.4%) but did not reach statistical significance.

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